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Target
CAAX prenyl protease 1 homolog
Ligand
BDBM558
Substrate
n/a
Meas. Tech.
ChEMBL_476919 (CHEMBL924570)
IC50
1200±n/a nM
Citation
 Coffinier, C; Hudon, SE; Farber, EA; Chang, SY; Hrycyna, CA; Young, SG; Fong, LG HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A 104:13432-7 (2007) [PubMed]  Article 
Target
Name:
CAAX prenyl protease 1 homolog
Synonyms:
FACE-1 | FACE1_MOUSE | Face1 | Farnesylated proteins-converting enzyme 1 | Prenyl protein-specific endoprotease 1 | Zinc metalloproteinase Ste24 homolog | Zmpste24
Type:
PROTEIN
Mol. Mass.:
54735.85
Organism:
Mus musculus
Description:
ChEMBL_476919
Residue:
475
Sequence:
MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTRVPAELEQIMDSDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFGGIPYLWRLSGQFCSSAGFGPEYEIIQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTLEFFMKDAIKKFIVTQCILLPVSALLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEESGMEARNEGEGDSEEVKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSTWHYSHPPLLERLQALKNAKQD
  
Inhibitor
Name:
BDBM558
Synonyms:
N-{3-[(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl]phenyl}-5-(trifluoromethyl)pyridine-2-sulfonamide | PNU-140690 | Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones | Tipranavir | U-140690
Type:
Small organic molecule
Emp. Form.:
C31H33F3N2O5S
Mol. Mass.:
602.664
SMILES:
CCC[C@@]1(CCc2ccccc2)CC(=O)C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(cn3)C(F)(F)F)c2)C(=O)O1 |r|
Structure:
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