Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50376788
Substrate
n/a
Meas. Tech.
ChEMBL_477818 (CHEMBL931250)
Ki
0.5±n/a nM
Citation
 Hall, A; Billinton, A; Brown, SH; Chowdhury, A; Giblin, GM; Goldsmith, P; Hurst, DN; Naylor, A; Patel, S; Scoccitti, T; Theobald, PJ Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping. Bioorg Med Chem Lett 18:2684-90 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50376788
Synonyms:
CHEMBL257997
Type:
Small organic molecule
Emp. Form.:
C16H14ClN2O2S
Mol. Mass.:
333.813
SMILES:
CC(C)Cc1cn(-c2nc(cs2)C([O-])=O)c2cc(Cl)ccc12
Structure:
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