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Target
Thrombopoietin receptor
Ligand
BDBM50219671
Substrate
n/a
Meas. Tech.
ChEMBL_479602 (CHEMBL926798)
EC50
140±n/a nM
Citation
 Reiter, LA; Jones, CS; Brissette, WH; McCurdy, SP; Abramov, YA; Bordner, J; DiCapua, FM; Munchhof, MJ; Rescek, DM; Samardjiev, IJ; Withka, JM Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett 18:3000-6 (2008) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50219671
Synonyms:
4-(pyrimidin-4-ylamino)-N-(6-(trifluoromethyl)-4H-chromeno[4,3-d]thiazol-2-yl)benzamide | CHEMBL399357
Type:
Small organic molecule
Emp. Form.:
C22H14F3N5O2S
Mol. Mass.:
469.439
SMILES:
FC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3COc12
Structure:
Search PDB for entries with ligand similarity: