Reaction Details Report a problem with these data
Target
Galanin receptor type 1
Ligand
BDBM50273372
Substrate
n/a
Meas. Tech.
ChEMBL_561969 (CHEMBL1010032)
Kd
34000±n/a nM
Citation
 Bulaj, G; Green, BR; Lee, HK; Robertson, CR; White, K; Zhang, L; Sochanska, M; Flynn, SP; Scholl, EA; Pruess, TH; Smith, MD; White, HS Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities. J Med Chem 51:8038-47 (2008) [PubMed]  Article 
Target
Name:
Galanin receptor type 1
Synonyms:
GAL1-R | GALNR | GALNR1 | GALR1 | GALR1_HUMAN | Galanin R1 | Galanin receptor 1 | Galanin receptor type 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38976.60
Organism:
Homo sapiens (Human)
Description:
Galanin R1 GALR1 HUMAN::P47211
Residue:
349
Sequence:
MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
  
Inhibitor
Name:
BDBM50273372
Synonyms:
CHEMBL503924 | galmic
Type:
Small organic molecule
Emp. Form.:
C51H61N10O11
Mol. Mass.:
990.0899
SMILES:
COC(=O)[C@H](CCCC[NH3+])NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc1oc2C)C(=O)NCC1CCCCC1)C(=O)NC1c2ccccc2-c2ccccc12 |r|
Structure:
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