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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50246056
Substrate
n/a
Meas. Tech.
ChEMBL_558180 (CHEMBL962314)
IC50
483±n/a nM
Citation
 Zhang, P; Terefenko, EA; McComas, CC; Mahaney, PE; Vu, A; Trybulski, E; Koury, E; Johnston, G; Bray, J; Deecher, D Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors. Bioorg Med Chem Lett 18:6067-70 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50246056
Synonyms:
(R)-4-fluoro-1-(2-fluorophenyl)-3-(3-(methylamino)-1-phenylpropyl)-1H-benzo[d]imidazol-2(3H)-one | CHEMBL511827
Type:
Small organic molecule
Emp. Form.:
C23H21F2N3O
Mol. Mass.:
393.4291
SMILES:
CNCC[C@H](c1ccccc1)n1c2c(F)cccc2n(-c2ccccc2F)c1=O |r,wU:4.11,(7.94,-18.99,;6.61,-19.76,;5.27,-18.98,;3.95,-19.76,;2.61,-18.99,;2.61,-17.45,;3.94,-16.69,;3.94,-15.15,;2.6,-14.38,;1.27,-15.16,;1.28,-16.7,;1.28,-19.76,;-.08,-19.19,;-.5,-17.7,;.58,-16.59,;-1.99,-17.32,;-3.06,-18.42,;-2.65,-19.91,;-1.15,-20.29,;-.38,-21.62,;-1,-23.03,;-2.54,-23.19,;-3.16,-24.6,;-2.25,-25.84,;-.71,-25.67,;-.1,-24.27,;1.43,-24.09,;1.12,-21.3,;2.27,-22.33,)|
Structure:
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