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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50245896
Substrate
n/a
Meas. Tech.
ChEMBL_559402 (CHEMBL1017256)
IC50
16550±n/a nM
Citation
 Lin, L; Shen, Q; Chen, GR; Xie, J Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors. Bioorg Med Chem Lett 18:6348-51 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50245896
Synonyms:
(2S,3R,4R,5S,6S)-3,4,5-triacetoxy-6-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-tetrahydro-2H-pyran-2-carboxylic acid | CHEMBL462016
Type:
Small organic molecule
Emp. Form.:
C22H20O11
Mol. Mass.:
460.3876
SMILES:
CC(=O)O[C@H]1[C@@H](OC(C)=O)[C@H](O[C@H]([C@@H]1OC(C)=O)C1=CC(=O)c2ccccc2C1=O)C(O)=O |r,t:19|
Structure:
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