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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50245898
Substrate
n/a
Meas. Tech.
ChEMBL_559402 (CHEMBL1017256)
IC50
2440±n/a nM
Citation
 Lin, L; Shen, Q; Chen, GR; Xie, J Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors. Bioorg Med Chem Lett 18:6348-51 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50245898
Synonyms:
2-((((2R,3R,4R,5S,6S)-3,4,5-tris(benzoyloxy)-6-(2,5-dimethoxyphenyl)-tetrahydro-2H-pyran-2-yl)methyl)carbamoyl)benzoic acid | CHEMBL503860
Type:
Small organic molecule
Emp. Form.:
C43H37NO12
Mol. Mass.:
759.7534
SMILES:
COc1ccc(OC)c(c1)[C@@H]1O[C@H](CNC(=O)c2ccccc2C(O)=O)[C@@H](OC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1 |r|
Structure:
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