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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50246115
Substrate
n/a
Meas. Tech.
ChEMBL_559402 (CHEMBL1017256)
IC50
5270±n/a nM
Citation
 Lin, L; Shen, Q; Chen, GR; Xie, J Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors. Bioorg Med Chem Lett 18:6348-51 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50246115
Synonyms:
(2S,3S,4S,5R,6R)-6-(benzamidomethyl)-2-(3,6-dioxocyclohexa-1,4-dienyl)-5-hydroxytetrahydro-2H-pyran-3,4-diyl dibenzoate | CHEMBL451520
Type:
Small organic molecule
Emp. Form.:
C33H27NO9
Mol. Mass.:
581.5688
SMILES:
O[C@@H]1[C@@H](CNC(=O)c2ccccc2)O[C@H]([C@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1)C1=CC(=O)C=CC1=O |r,c:43,t:39|
Structure:
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