Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50252901
Substrate
n/a
Meas. Tech.
ChEMBL_539394 (CHEMBL1027278)
EC50
8.03±n/a nM
Citation
 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity. J Med Chem 51:5585-93 (2008) [PubMed]  Article 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC5R_MOUSE | Mc5r | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36966.58
Organism:
Mus musculus (Mouse)
Description:
P41149
Residue:
325
Sequence:
MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
  
Inhibitor
Name:
BDBM50252901
Synonyms:
Ac-His-DPhe(pCF3)-Arg-Trp-NH2 | CHEMBL501679
Type:
Small organic molecule
Emp. Form.:
C35H42F3N11O5
Mol. Mass.:
753.7739
SMILES:
CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(cc1)C(F)(F)F)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:4.3,14.14,29.30,wD:40.41,(-8.35,-34.02,;-8.35,-35.57,;-9.68,-36.33,;-7.02,-36.34,;-5.68,-35.57,;-5.68,-34.03,;-4.35,-33.25,;-2.94,-33.89,;-1.9,-32.74,;-2.67,-31.41,;-4.18,-31.72,;-4.35,-36.34,;-4.35,-37.88,;-3.01,-35.57,;-1.68,-36.34,;-1.68,-37.88,;-.35,-38.66,;-.35,-40.19,;.99,-40.96,;2.31,-40.2,;2.32,-38.66,;.99,-37.88,;3.65,-40.97,;4.97,-41.74,;2.88,-42.3,;4.43,-39.64,;-.35,-35.58,;-.35,-34.03,;.99,-36.34,;2.32,-35.57,;2.32,-34.04,;3.65,-33.26,;3.65,-31.73,;4.99,-30.96,;4.99,-29.42,;3.66,-28.65,;6.33,-28.65,;3.65,-36.34,;3.65,-37.89,;4.99,-35.58,;6.33,-36.35,;6.33,-37.89,;7.66,-38.66,;9.07,-38.03,;10.09,-39.18,;9.32,-40.52,;9.79,-41.98,;8.77,-43.13,;7.26,-42.81,;6.78,-41.34,;7.82,-40.2,;7.66,-35.58,;9,-36.35,;7.66,-34.05,)|
Structure:
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