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Target
Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50275090
Substrate
n/a
Meas. Tech.
ChEMBL_495134 (CHEMBL1008913)
Kd
47±n/a nM
Citation
 Sørensen, US; Strøbaek, D; Christophersen, P; Hougaard, C; Jensen, ML; Nielsen, EŘ; Peters, D; Teuber, L Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem 51:7625-34 (2009) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2 | KCNN2_HUMAN | SK2
Type:
PROTEIN
Mol. Mass.:
63788.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_480083
Residue:
579
Sequence:
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
  
Inhibitor
Name:
BDBM50275090
Synonyms:
(1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetrahydronaphthalen-1-yl)amine | CHEMBL511710
Type:
Small organic molecule
Emp. Form.:
C17H15Cl2N3
Mol. Mass.:
332.227
SMILES:
Clc1cc2CCCC(Nc3nc4ccccc4[nH]3)c2cc1Cl
Structure:
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