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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50275773
Substrate
n/a
Meas. Tech.
ChEMBL_493245 (CHEMBL948475)
IC50
>10000±n/a nM
Citation
 Dyck, B; Tamiya, J; Jovic, F; Pick, RR; Bradbury, MJ; O'Brien, J; Wen, J; Johns, M; Madan, A; Fleck, BA; Foster, AC; Li, B; Zhang, M; Tran, JA; Vickers, T; Grey, J; Saunders, J; Chen, C Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. J Med Chem 51:7265-72 (2009) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50275773
Synonyms:
CHEMBL469946 | N-Ethyl-N-(2-fluoroallyl) (1R,2R)-2-(Aminomethyl)-1-(2-thienyl)-cyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C14H19FN2OS
Mol. Mass.:
282.377
SMILES:
CCN(CC(F)=C)C(=O)[C@]1(C[C@H]1CN)c1cccs1 |r|
Structure:
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