Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50378056
Substrate
n/a
Meas. Tech.
ChEMBL_575368 (CHEMBL1027042)
Kd
4800±n/a nM
Citation
 Jiang, S; Liao, C; Bindu, L; Yin, B; Worthy, KW; Fisher, RJ; Burke, TR; Nicklaus, MC; Roller, PP Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg Med Chem Lett 19:2693-8 (2009) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50378056
Synonyms:
CHEMBL1627249
Type:
Small organic molecule
Emp. Form.:
C38H46N7O12PS
Mol. Mass.:
855.85
SMILES:
NC(=O)CC1NC(=O)C2(CCCCC2)NC(=O)C(Cc2ccc(OP(O)(O)=O)cc2)NC(=O)CS(=O)CC(NC(=O)C(Cc2ccc3ccccc3c2)NC1=O)C(N)=O
Structure:
Search PDB for entries with ligand similarity: