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Target
Serine/threonine-protein phosphatase 2A activator
Ligand
BDBM50307999
Substrate
n/a
Meas. Tech.
ChEMBL_608738 (CHEMBL1067751)
IC50
49700±n/a nM
Citation
 Ye, D; Zhang, Y; Wang, F; Zheng, M; Zhang, X; Luo, X; Shen, X; Jiang, H; Liu, H Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity. Bioorg Med Chem 18:1773-82 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A activator
Synonyms:
5.2.1.8 | PPP2R4 | PTPA | PTPA_HUMAN | Phosphotyrosyl phosphatase activator | Protein phosphatase 2A regulatory subunit B | Protein phosphatase 2A regulatory subunit B' | Serine/threonine-protein phosphatase 2A activator | Serine/threonine-protein phosphatase 2A regulatory subunit 4
Type:
n/a
Mol. Mass.:
40662.53
Organism:
Homo sapiens (Human)
Description:
Q15257
Residue:
358
Sequence:
MAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
  
Inhibitor
Name:
BDBM50307999
Synonyms:
4-Biphenyl-4-yl-2-(2-carboxy-benzoylamino)-5-methylthiophene-3-carboxylic acid ethyl ester | CHEMBL599646
Type:
Small organic molecule
Emp. Form.:
C27H21NO5S
Mol. Mass.:
471.524
SMILES:
CCOC(=O)c1c(NC(=O)c2ccccc2C(O)=O)scc1-c1ccc(cc1)-c1ccccc1
Structure:
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