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Target
Serine/threonine-protein phosphatase 2A activator
Ligand
BDBM50308000
Substrate
n/a
Meas. Tech.
ChEMBL_608738 (CHEMBL1067751)
IC50
>100000±n/a nM
Citation
 Ye, D; Zhang, Y; Wang, F; Zheng, M; Zhang, X; Luo, X; Shen, X; Jiang, H; Liu, H Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity. Bioorg Med Chem 18:1773-82 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A activator
Synonyms:
5.2.1.8 | PPP2R4 | PTPA | PTPA_HUMAN | Phosphotyrosyl phosphatase activator | Protein phosphatase 2A regulatory subunit B | Protein phosphatase 2A regulatory subunit B' | Serine/threonine-protein phosphatase 2A activator | Serine/threonine-protein phosphatase 2A regulatory subunit 4
Type:
n/a
Mol. Mass.:
40662.53
Organism:
Homo sapiens (Human)
Description:
Q15257
Residue:
358
Sequence:
MAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
  
Inhibitor
Name:
BDBM50308000
Synonyms:
3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-(thiazol-2-yl)benzofuran-6-sulfonamide | CHEMBL598832
Type:
Small organic molecule
Emp. Form.:
C20H14Br2N2O5S2
Mol. Mass.:
586.274
SMILES:
CCc1oc2cc(ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1)S(=O)(=O)Nc1nccs1
Structure:
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