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Target
D(4) dopamine receptor
Ligand
BDBM50055810
Substrate
n/a
Meas. Tech.
ChEMBL_608751 (CHEMBL1067764)
Ki
3.6±n/a nM
Citation
 Neves, G; Menegatti, R; Antonio, CB; Grazziottin, LR; Vieira, RO; Rates, SM; Noël, F; Barreiro, EJ; Fraga, CA Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorg Med Chem 18:1925-35 (2010) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50055810
Synonyms:
1-Phenyl-4-(2-phenyl-3H-imidazol-4-ylmethyl)-piperazine | 1-phenyl-4-((2-phenyl-1H-imidazol-4-yl)methyl)piperazine | CHEMBL103871
Type:
Small organic molecule
Emp. Form.:
C20H22N4
Mol. Mass.:
318.4155
SMILES:
C(N1CCN(CC1)c1ccccc1)c1cnc([nH]1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: