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Target
Mitogen-activated protein kinase 14
Ligand
BDBM14771
Substrate
n/a
Meas. Tech.
ChEMBL_613377 (CHEMBL1067575)
IC50
960±n/a nM
Citation
 Ehrman, TM; Barlow, DJ; Hylands, PJ In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem 18:2204-18 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM14771
Synonyms:
(E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylidene}amino carbamate | Filaminast | [1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino] carbamate
Type:
Small organic molecule
Emp. Form.:
C15H20N2O4
Mol. Mass.:
292.3303
SMILES:
COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18|
Structure:
Search PDB for entries with ligand similarity: