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Target
Kappa-type opioid receptor
Ligand
BDBM50316621
Substrate
n/a
Meas. Tech.
ChEMBL_631958 (CHEMBL1104714)
Ki
2.4±n/a nM
Citation
 Geiger, C; Zelenka, C; Lehmkuhl, K; Schepmann, D; Englberger, W; Wünsch, B Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives. J Med Chem 53:4212-22 (2010) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50316621
Synonyms:
(R)-methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-((R)-1-(pyrrolidin-1-yl)ethyl)piperazine-1-carboxylate | CHEMBL1095519
Type:
Small organic molecule
Emp. Form.:
C20H27Cl2N3O3
Mol. Mass.:
428.353
SMILES:
COC(=O)N1CCN([C@H](C1)[C@@H](C)N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Structure:
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