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Target
Thrombopoietin receptor
Ligand
BDBM50321636
Substrate
n/a
Meas. Tech.
ChEMBL_639843 (CHEMBL1173858)
EC50
574±n/a nM
Citation
 Antipas, AS; Blumberg, LC; Brissette, WH; Brown, MF; Casavant, JM; Doty, JL; Driscoll, J; Harris, TM; Jones, CS; McCurdy, SP; McElroy, E; Mitton-Fry, M; Munchhof, MJ; Reim, DA; Reiter, LA; Ripp, SL; Shavnya, A; Smeets, MI; Trevena, KA Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor. Bioorg Med Chem Lett 20:4069-72 (2010) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50321636
Synonyms:
1-(3-chloro-5-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid | CHEMBL1169647
Type:
Small organic molecule
Emp. Form.:
C21H16ClF4N5O3S
Mol. Mass.:
529.895
SMILES:
OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(ns1)-c1ccc(F)c(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: