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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50322698
Substrate
n/a
Meas. Tech.
ChEMBL_642191 (CHEMBL1176742)
Ki
1.58±n/a nM
Citation
 Micheli, F; Cavanni, P; Andreotti, D; Arban, R; Benedetti, R; Bertani, B; Bettati, M; Bettelini, L; Bonanomi, G; Braggio, S; Carletti, R; Checchia, A; Corsi, M; Fazzolari, E; Fontana, S; Marchioro, C; Merlo-Pich, E; Negri, M; Oliosi, B; Ratti, E; Read, KD; Roscic, M; Sartori, I; Spada, S; Tedesco, G; Tarsi, L; Terreni, S; Visentini, F; Zocchi, A; Zonzini, L; Di Fabio, R 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem 53:4989-5001 (2010) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | Htt | SC6A4_MOUSE | Serotonin transporter | Sert | Slc6a4 | Sodium-dependent serotonin transporter | Solute carrier family 6 member 4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70044.92
Organism:
MOUSE
Description:
5-HT Transporter SLC6A4 MOUSE::Q60857
Residue:
630
Sequence:
METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQISNGYSAVPSTSAGDEAPHSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50322698
Synonyms:
rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-azabicyclo[4.1.0]heptane
Type:
Small organic molecule
Emp. Form.:
C14H17Cl2NO
Mol. Mass.:
286.197
SMILES:
COC[C@]12C[C@]1(CCNC2)c1ccc(Cl)c(Cl)c1 |r|
Structure:
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