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Target
Dihydrofolate reductase
Ligand
BDBM50326680
Substrate
n/a
Meas. Tech.
ChEMBL_662068 (CHEMBL1251878)
IC50
1800±n/a nM
Citation
 Marques, SM; Enyedy, EA; Supuran, CT; Krupenko, NI; Krupenko, SA; Santos, MA Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem 18:5081-9 (2010) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
  
Inhibitor
Name:
BDBM50326680
Synonyms:
4-((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)-N-(4-sulfamoylphenethyl)-benzamide | CHEMBL1255024
Type:
Small organic molecule
Emp. Form.:
C23H25N9O3S
Mol. Mass.:
507.568
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NCCc1ccc(cc1)S(N)(=O)=O
Structure:
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