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Target
Sodium- and chloride-dependent glycine transporter 2
Ligand
BDBM50335006
Substrate
n/a
Meas. Tech.
ChEMBL_702706 (CHEMBL1657780)
IC50
260±n/a nM
Citation
 Kohara, A; Doihara, H; Saita, K; Aota, M Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as novel glycine transporter 1 inhibitors. J Med Chem 54:387-91 (2011) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 2
Synonyms:
Glycine transporter 2 | Glyt2 | SC6A5_RAT | Slc6a5
Type:
PROTEIN
Mol. Mass.:
87845.43
Organism:
Rattus norvegicus
Description:
ChEMBL_980598
Residue:
799
Sequence:
MDCSAPKEMNKPPTNILEATVPGHRDSPRAPRTSPEQDLPAAAPAAAVQPPRVPRSASTGAQTFQSADARACEAQRPGVGFCKLSSPQAQATSAALRDLSEGHSAQANPPSGAAGAGNALHCKIPALRGPEEDENVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
  
Inhibitor
Name:
BDBM50335006
Synonyms:
2-(3-Biphenyl-4-yl-5-methyl-4H-1,2,4-triazole-4-yl)benzonitrile | CHEMBL1649956
Type:
Small organic molecule
Emp. Form.:
C22H16N4
Mol. Mass.:
336.3892
SMILES:
Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C#N |(2.17,-22.75,;.7,-22.27,;.23,-20.8,;-1.31,-20.8,;-1.79,-22.27,;-3.11,-23.04,;-3.11,-24.59,;-4.44,-25.36,;-5.77,-24.59,;-5.78,-23.06,;-4.46,-22.28,;-7.1,-25.36,;-8.43,-24.6,;-9.76,-25.37,;-9.77,-26.92,;-8.43,-27.69,;-7.09,-26.91,;-.55,-23.17,;-.55,-24.71,;-1.88,-25.47,;-1.89,-27.01,;-.55,-27.78,;.79,-27.01,;.78,-25.47,;2.11,-24.7,;3.44,-23.93,)|
Structure:
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