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Target
Cytochrome P450 2D6
Ligand
BDBM50335917
Substrate
n/a
Meas. Tech.
ChEMBL_717287 (CHEMBL1669910)
IC50
>100000±n/a nM
Citation
 Tezuka, Y; Morikawa, K; Li, F; Auw, L; Awale, S; Nobukawa, T; Kadota, S Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis. J Nat Prod 74:102-5 (2011) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50335917
Synonyms:
(3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol | CHEMBL1668108
Type:
Small organic molecule
Emp. Form.:
C16H16O4
Mol. Mass.:
272.2958
SMILES:
COc1cc(ccc1O)[C@H]1COc2ccccc2[C@@H]1O |r|
Structure:
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