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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50417985
Substrate
n/a
Meas. Tech.
ChEMBL_718702 (CHEMBL1680921)
IC50
19.95±n/a nM
Citation
 Tanaka, D; Tsuda, Y; Shiyama, T; Nishimura, T; Chiyo, N; Tominaga, Y; Sawada, N; Mimoto, T; Kusunose, N A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors. J Med Chem 54:851-7 (2012) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Ephx2 | Epoxide hydrolase 2 | HYES_RAT
Type:
PROTEIN
Mol. Mass.:
62337.15
Organism:
Rattus norvegicus
Description:
ChEMBL_1465995
Residue:
554
Sequence:
MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITFSQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTCIVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYVTVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPLMPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNKATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALGRKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKWLKTEIQNPSVTSKI
  
Inhibitor
Name:
BDBM50417985
Synonyms:
CHEMBL1672130
Type:
Small organic molecule
Emp. Form.:
C18H17N3O2
Mol. Mass.:
307.3465
SMILES:
Cc1nc2cc(NC(=O)N[C@H]3C[C@@H]3c3ccccc3)ccc2o1 |r|
Structure:
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