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Target
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Ligand
BDBM50078117
Substrate
n/a
Meas. Tech.
ChEMBL_736246 (CHEMBL1693390)
IC50
150±n/a nM
Citation
 Poláková, M; Šeták, S; Lattová, E; Petruš, L; Mucha, J; Tvaroška, I; Kóna, J a-D-mannose derivatives as models designed for selective inhibition of Golgia-mannosidase II. Eur J Med Chem 46:944-52 (2011) [PubMed]  Article 
Target
Name:
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Synonyms:
MA1A1_DROME | Man(9)-alpha-mannosidase | Mannosidase-1 | Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B | alpha-Man-Ia | alpha-man-1 | mas-1
Type:
PROTEIN
Mol. Mass.:
74961.37
Organism:
Drosophila melanogaster
Description:
ChEMBL_103952
Residue:
667
Sequence:
MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS
  
Inhibitor
Name:
BDBM50078117
Synonyms:
(1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL | (1R,2R,3R,4S,5R)-4-Amino-5-methylsulfanyl-cyclopentane-1,2,3-triol | CHEMBL9623 | Mannostatin A, 1 | Mannostatin A, 1a
Type:
Small organic molecule
Emp. Form.:
C6H13NO3S
Mol. Mass.:
179.237
SMILES:
CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Structure:
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