Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50379591
Substrate
n/a
Meas. Tech.
ChEMBL_811654 (CHEMBL2014167)
Ki
1.8±n/a nM
Citation
 Wu, L; Lu, K; Packiarajan, M; Jubian, V; Chandrasena, G; Wolinsky, TC; Walker, MW Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists. Bioorg Med Chem Lett 22:2167-71 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50379591
Synonyms:
CHEMBL2013017
Type:
Small organic molecule
Emp. Form.:
C21H33N3O3S
Mol. Mass.:
407.57
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CCN1CCc2ccccc12 |r,wU:8.7,wD:11.14,(33.54,-33.77,;32.21,-33,;32.21,-31.46,;30.87,-33.76,;31.64,-35.09,;30.1,-35.08,;29.54,-32.99,;28.21,-33.76,;26.87,-32.99,;25.54,-33.75,;24.21,-32.99,;24.21,-31.45,;25.54,-30.67,;26.87,-31.45,;22.88,-30.68,;21.55,-31.46,;21.55,-33,;20.21,-30.69,;18.88,-31.46,;17.54,-30.69,;16.18,-31.4,;15.07,-30.32,;15.76,-28.95,;15.19,-27.53,;16.14,-26.32,;17.67,-26.54,;18.23,-27.97,;17.28,-29.17,)|
Structure:
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