Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50379597
Substrate
n/a
Meas. Tech.
ChEMBL_811654 (CHEMBL2014167)
Ki
0.9±n/a nM
Citation
 Wu, L; Lu, K; Packiarajan, M; Jubian, V; Chandrasena, G; Wolinsky, TC; Walker, MW Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists. Bioorg Med Chem Lett 22:2167-71 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50379597
Synonyms:
CHEMBL2013010
Type:
Small organic molecule
Emp. Form.:
C19H26ClN3O4S2
Mol. Mass.:
460.01
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)Cn1c2ccc(Cl)cc2sc1=O |r,wU:8.7,wD:11.14,(10.44,-12.14,;9.11,-11.36,;9.11,-9.82,;7.77,-12.13,;8.53,-13.46,;7,-13.45,;6.44,-11.36,;5.1,-12.13,;3.77,-11.36,;2.44,-12.12,;1.11,-11.36,;1.11,-9.82,;2.44,-9.04,;3.77,-9.82,;-.22,-9.05,;-1.56,-9.82,;-1.55,-11.36,;-2.89,-9.06,;-4.22,-9.83,;-5.63,-9.21,;-6.11,-7.75,;-7.62,-7.43,;-8.65,-8.58,;-10.15,-8.27,;-8.16,-10.04,;-6.67,-10.35,;-5.89,-11.69,;-4.39,-11.36,;-3.24,-12.39,)|
Structure:
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