Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50379604
Substrate
n/a
Meas. Tech.
ChEMBL_811654 (CHEMBL2014167)
Ki
1.2±n/a nM
Citation
 Wu, L; Lu, K; Packiarajan, M; Jubian, V; Chandrasena, G; Wolinsky, TC; Walker, MW Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists. Bioorg Med Chem Lett 22:2167-71 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50379604
Synonyms:
CHEMBL2013024
Type:
Small organic molecule
Emp. Form.:
C20H28FN3O3S
Mol. Mass.:
409.518
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)Cn1ccc2ccc(F)cc12 |r,wU:8.7,wD:11.14,(36.74,-.05,;35.41,.72,;35.41,2.26,;34.07,-.04,;34.83,-1.37,;33.3,-1.36,;32.74,.73,;31.4,-.04,;30.07,.73,;28.74,-.03,;27.41,.73,;27.41,2.27,;28.74,3.05,;30.07,2.27,;26.08,3.04,;24.74,2.26,;24.75,.72,;23.41,3.03,;22.08,2.26,;21.91,.73,;20.4,.4,;19.63,1.73,;18.13,2.05,;17.65,3.5,;18.68,4.66,;18.2,6.12,;20.19,4.34,;20.66,2.88,)|
Structure:
Search PDB for entries with ligand similarity: