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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50383112
Substrate
n/a
Meas. Tech.
ChEMBL_818778 (CHEMBL2033464)
IC50
1.7±n/a nM
Citation
 Kamata, M; Yamashita, T; Imaeda, T; Tanaka, T; Masada, S; Kamaura, M; Kasai, S; Hara, R; Sasaki, S; Takekawa, S; Asami, A; Kaisho, T; Suzuki, N; Ashina, S; Ogino, H; Nakano, Y; Nagisa, Y; Kato, K; Kato, K; Ishihara, Y Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines. J Med Chem 55:2353-66 (2012) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50383112
Synonyms:
CHEMBL2029372
Type:
Small organic molecule
Emp. Form.:
C28H26FN3O
Mol. Mass.:
439.5239
SMILES:
Cc1c(NC(=O)c2ccc(cc2)-c2ccc(F)cc2)ccc2cc(CN3CCCC3)cnc12
Structure:
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