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Target
Peptide deformylase
Ligand
BDBM50383993
Substrate
n/a
Meas. Tech.
ChEMBL_819736 (CHEMBL2034166)
IC50
1.6±n/a nM
Citation
 Axten, JM; Medina, JR; Blackledge, CW; Duquenne, C; Grant, SW; Bobko, MA; Peng, T; Miller, WH; Pinckney, T; Gallagher, TF; Kulkarni, S; Lewandowski, T; Van Aller, GS; Zonis, R; Ward, P; Campobasso, N Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Bioorg Med Chem Lett 22:4028-32 (2012) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_STAAM | PDF | Polypeptide deformylase | def | def1 | pdf1
Type:
Enzyme
Mol. Mass.:
20556.80
Organism:
Staphylococcus aureus
Description:
P68825
Residue:
183
Sequence:
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
  
Inhibitor
Name:
BDBM50383993
Synonyms:
CHEMBL2032131
Type:
Small organic molecule
Emp. Form.:
C19H32N4O5
Mol. Mass.:
396.4812
SMILES:
CC(C)NC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O |r|
Structure:
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