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Target
Histamine H3 receptor
Ligand
BDBM50333504
Substrate
n/a
Meas. Tech.
ChEMBL_826695 (CHEMBL2051142)
Ki
49±n/a nM
Citation
 Rao, AU; Shao, N; Aslanian, RG; Chan, TY; Degrado, SJ; Wang, L; McKittrick, B; Senior, M; West, RE; Williams, SM; Wu, RL; Hwa, J; Patel, B; Zheng, S; Sondey, C; Palani, A Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes. ACS Med Chem Lett 3:198-202 (2012) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50333504
Synonyms:
1-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-yl)-3-cyclopentylurea | CHEMBL1641821
Type:
Small organic molecule
Emp. Form.:
C18H30N6OS
Mol. Mass.:
378.535
SMILES:
O=C(NC1CCCC1)Nc1nnc(s1)N1CCC(CC1)N1CCCCC1
Structure:
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