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Target
Renin
Ligand
BDBM50387280
Substrate
n/a
Meas. Tech.
ChEMBL_827989 (CHEMBL2051644)
IC50
6.4±n/a nM
Citation
 Nakamura, Y; Sugita, C; Meguro, M; Miyazaki, S; Tamaki, K; Takahashi, M; Nagai, Y; Nagayama, T; Kato, M; Suemune, H; Nishi, T Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors. Bioorg Med Chem Lett 22:4561-6 (2012) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_MACFA
Type:
PROTEIN
Mol. Mass.:
45012.96
Organism:
Macaca fascicularis
Description:
ChEMBL_979177
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLALGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNILSQGVLKEDVFSFYYNRDSENAQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50387280
Synonyms:
CHEMBL2046465
Type:
Small organic molecule
Emp. Form.:
C28H47N5O6
Mol. Mass.:
549.7027
SMILES:
COCOc1ccccc1N1CC(C)(C)N(C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)CC1=O |r|
Structure:
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