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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50389078
Substrate
n/a
Meas. Tech.
ChEMBL_833720 (CHEMBL2066819)
IC50
129±n/a nM
Citation
 Lo Monte, F; Kramer, T; Gu, J; Anumala, UR; Marinelli, L; La Pietra, V; Novellino, E; Franco, B; Demedts, D; Van Leuven, F; Fuertes, A; Dominguez, JM; Plotkin, B; Eldar-Finkelman, H; Schmidt, B Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3a. J Med Chem 55:4407-24 (2012) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50389078
Synonyms:
CHEMBL2064539
Type:
Small organic molecule
Emp. Form.:
C26H21N3O4S
Mol. Mass.:
471.528
SMILES:
COC[C@H]1COc2ccc(cc2O1)-c1nnc(SCc2ccc(cc2)-c2ccccc2C#N)o1 |r|
Structure:
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