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Target
Glycogen synthase kinase-3 alpha
Ligand
BDBM69279
Substrate
n/a
Meas. Tech.
ChEMBL_833721 (CHEMBL2066820)
IC50
7379±n/a nM
Citation
 Lo Monte, F; Kramer, T; Gu, J; Anumala, UR; Marinelli, L; La Pietra, V; Novellino, E; Franco, B; Demedts, D; Van Leuven, F; Fuertes, A; Dominguez, JM; Plotkin, B; Eldar-Finkelman, H; Schmidt, B Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3a. J Med Chem 55:4407-24 (2012) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 alpha
Synonyms:
GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha)
Type:
Enzyme
Mol. Mass.:
50991.79
Organism:
Homo sapiens (Human)
Description:
P49840
Residue:
483
Sequence:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
  
Inhibitor
Name:
BDBM69279
Synonyms:
4-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]benzenecarbonitrile | 4-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]benzonitrile | 4-[[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)thio]methyl]benzonitrile | 4-[[[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrile | MLS000687325 | SMR000285069 | cid_1467927
Type:
Small organic molecule
Emp. Form.:
C15H10N4OS
Mol. Mass.:
294.331
SMILES:
N#Cc1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Structure:
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