Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50391344
Substrate
n/a
Meas. Tech.
ChEMBL_847915 (CHEMBL2150114)
IC50
1600±n/a nM
Citation
 Miyahara, S; Miyakoshi, H; Yokogawa, T; Chong, KT; Taguchi, J; Muto, T; Endoh, K; Yano, W; Wakasa, T; Ueno, H; Takao, Y; Fujioka, A; Hashimoto, A; Itou, K; Yamamura, K; Nomura, M; Nagasawa, H; Shuto, S; Fukuoka, M Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy. J Med Chem 55:5483-96 (2012) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM50391344
Synonyms:
CHEMBL2147973
Type:
Small organic molecule
Emp. Form.:
C18H23N3O4S
Mol. Mass.:
377.458
SMILES:
CC(C)(CC\C=C\Cn1ccc(=O)[nH]c1=O)NS(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: