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Target
Acyl-CoA 6-desaturase
Ligand
BDBM50393166
Substrate
n/a
Meas. Tech.
ChEMBL_852951 (CHEMBL2154135)
IC50
>100000000±n/a nM
Citation
 Oballa, RM; Belair, L; Black, WC; Bleasby, K; Chan, CC; Desroches, C; Du, X; Gordon, R; Guay, J; Guiral, S; Hafey, MJ; Hamelin, E; Huang, Z; Kennedy, B; Lachance, N; Landry, F; Li, CS; Mancini, J; Normandin, D; Pocai, A; Powell, DA; Ramtohul, YK; Skorey, K; Sørensen, D; Sturkenboom, W; Styhler, A; Waddleton, DM; Wang, H; Wong, S; Xu, L; Zhang, L Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem 54:5082-96 (2011) [PubMed]  Article 
Target
Name:
Acyl-CoA 6-desaturase
Synonyms:
FADS2 | FADS2_HUMAN | Fatty acid desaturase 2
Type:
PROTEIN
Mol. Mass.:
52278.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_852951
Residue:
444
Sequence:
MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYLHK
  
Inhibitor
Name:
BDBM50393166
Synonyms:
CHEMBL2153601
Type:
Small organic molecule
Emp. Form.:
C16H15BrFN7O3S
Mol. Mass.:
484.303
SMILES:
OC(=O)Cn1nnc(n1)-c1nnc(s1)N1CCC(CC1)Oc1cc(F)ccc1Br
Structure:
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