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Target
Quinolone resistance protein NorA
Ligand
BDBM50393706
Substrate
n/a
Meas. Tech.
ChEMBL_856643 (CHEMBL2162180)
IC50
7700±n/a nM
Citation
 Holler, JG; Slotved, HC; Mølgaard, P; Olsen, CE; Christensen, SB Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles. Bioorg Med Chem 20:4514-21 (2012) [PubMed]  Article 
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50393706
Synonyms:
CHEMBL2158999
Type:
Small organic molecule
Emp. Form.:
C21H26N2O2
Mol. Mass.:
338.4433
SMILES:
CN(C)CCOc1ccc(cc1)C(=O)\C=C\c1ccc(cc1)N(C)C
Structure:
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