Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50395043
Substrate
n/a
Meas. Tech.
ChEMBL_859059 (CHEMBL2169084)
IC50
210±n/a nM
Citation
 Miyakoshi, H; Miyahara, S; Yokogawa, T; Endoh, K; Muto, T; Yano, W; Wakasa, T; Ueno, H; Chong, KT; Taguchi, J; Nomura, M; Takao, Y; Fujioka, A; Hashimoto, A; Itou, K; Yamamura, K; Shuto, S; Nagasawa, H; Fukuoka, M 1,2,3-Triazole-containing uracil derivatives with excellent pharmacokinetics as a novel class of potent human deoxyuridine triphosphatase inhibitors. J Med Chem 55:6427-37 (2012) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM50395043
Synonyms:
CHEMBL2163857
Type:
Small organic molecule
Emp. Form.:
C25H33N5O4
Mol. Mass.:
467.5606
SMILES:
CC[C@@](O)(Cn1nncc1CCCCn1ccc(=O)[nH]c1=O)c1cccc(OC2CCCC2)c1 |r|
Structure:
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