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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50395303
Substrate
n/a
Meas. Tech.
ChEMBL_860552 (CHEMBL2167126)
IC50
360±n/a nM
Citation
 Kosugi, T; Mitchell, DR; Fujino, A; Imai, M; Kambe, M; Kobayashi, S; Makino, H; Matsueda, Y; Oue, Y; Komatsu, K; Imaizumi, K; Sakai, Y; Sugiura, S; Takenouchi, O; Unoki, G; Yamakoshi, Y; Cunliffe, V; Frearson, J; Gordon, R; Harris, CJ; Kalloo-Hosein, H; Le, J; Patel, G; Simpson, DJ; Sherborne, B; Thomas, PS; Suzuki, N; Takimoto-Kamimura, M; Kataoka, K Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. J Med Chem 55:6700-15 (2012) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM50395303
Synonyms:
CHEMBL2163981
Type:
Small organic molecule
Emp. Form.:
C21H28N6O
Mol. Mass.:
380.4866
SMILES:
CCOc1ccc(Nc2c(C)c(N[C@H]3CC[C@H](N)CC3)nc3ccnn23)cc1 |r,wU:13.12,wD:16.16,(27.41,-30.13,;26.07,-30.9,;24.74,-30.13,;23.41,-30.9,;23.4,-32.44,;22.07,-33.2,;20.74,-32.43,;19.4,-33.19,;19.4,-34.73,;20.73,-35.51,;22.06,-34.74,;20.73,-37.05,;22.06,-37.82,;23.4,-37.05,;23.39,-35.52,;24.74,-34.76,;26.07,-35.54,;27.41,-34.77,;26.06,-37.08,;24.73,-37.84,;19.4,-37.81,;18.07,-37.05,;16.6,-37.53,;15.69,-36.28,;16.6,-35.02,;18.07,-35.5,;20.73,-30.89,;22.06,-30.12,)|
Structure:
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