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Target
Betaine--homocysteine S-methyltransferase 1
Ligand
BDBM50395382
Substrate
n/a
Meas. Tech.
ChEMBL_857980 (CHEMBL2166488)
IC50
76600±n/a nM
Citation
 Mládková, J; Vanek, V; Budešínský, M; Elbert, T; Demianová, Z; Garrow, TA; Jirácek, J Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2. J Med Chem 55:6822-31 (2012) [PubMed]  Article 
Target
Name:
Betaine--homocysteine S-methyltransferase 1
Synonyms:
BHMT | BHMT1_HUMAN
Type:
PROTEIN
Mol. Mass.:
45000.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_970672
Residue:
406
Sequence:
MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ
  
Inhibitor
Name:
BDBM50395382
Synonyms:
CHEMBL2164724
Type:
Small organic molecule
Emp. Form.:
C12H24N2O4S
Mol. Mass.:
292.395
SMILES:
CC(CCSCC[C@H](N)C(O)=O)CCC(N)C(O)=O |r|
Structure:
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