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Target
Histamine H1 receptor
Ligand
BDBM67545
Substrate
n/a
Meas. Tech.
ChEMBL_858531 (CHEMBL2169535)
IC50
1258.93±n/a nM
Citation
 Vasudevan, SR; Moore, JB; Schymura, Y; Churchill, GC Shape-based reprofiling of FDA-approved drugs for the H1 histamine receptor. J Med Chem 55:7054-60 (2012) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
  
Inhibitor
Name:
BDBM67545
Synonyms:
N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;hydrochloride | N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine;hydrochloride | N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride | PROMAZINE | SR-01000000228-4 | US9504692, Promazine | cid_5887 | dimethyl(3-phenothiazin-10-ylpropyl)amine;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C17H20N2S
Mol. Mass.:
284.419
SMILES:
CN(C)CCCN1c2ccccc2Sc2ccccc12
Structure:
Search PDB for entries with ligand similarity: