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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50396329
Substrate
n/a
Meas. Tech.
ChEMBL_864296 (CHEMBL2175567)
IC50
26.5±n/a nM
Citation
 Aggarwal, S; Thareja, S; Bhardwaj, TR; Haupenthal, J; Hartmann, RW; Kumar, M Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5a-reductase inhibitors: a legitimate approach. Eur J Med Chem 54:728-39 (2012) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50396329
Synonyms:
CHEMBL2172647
Type:
Small organic molecule
Emp. Form.:
C25H35NO5
Mol. Mass.:
429.5491
SMILES:
CCOC(=O)CCN1C(=O)CC[C@H]2[C@@H]3CC=C4C=C(CC[C@]4(C)[C@H]3CC[C@]12C)C(O)=O |r,c:17,t:15|
Structure:
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