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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50396723
Substrate
n/a
Meas. Tech.
ChEMBL_864299 (CHEMBL2175570)
IC50
>100000±n/a nM
Citation
 Marwaha, A; White, J; El Mazouni, F; Creason, SA; Kokkonda, S; Buckner, FS; Charman, SA; Phillips, MA; Rathod, PK Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. J Med Chem 55:7425-36 (2012) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50396723
Synonyms:
CHEMBL2172226 | US9238653, Table 5, Compound 2
Type:
Small organic molecule
Emp. Form.:
C14H11F3N4
Mol. Mass.:
292.2591
SMILES:
Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2ccnc2n1
Structure:
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