Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50388626
Substrate
n/a
Meas. Tech.
ChEMBL_874354 (CHEMBL2182652)
Kd
0.4±n/a nM
Citation
Rew, Y; Sun, D; Gonzalez-Lopez De Turiso, F; Bartberger, MD; Beck, HP; Canon, J; Chen, A; Chow, D; Deignan, J; Fox, BM; Gustin, D; Huang, X; Jiang, M; Jiao, X; Jin, L; Kayser, F; Kopecky, DJ; Li, Y; Lo, MC; Long, AM; Michelsen, K; Oliner, JD; Osgood, T; Ragains, M; Saiki, AY; Schneider, S; Toteva, M; Yakowec, P; Yan, X; Ye, Q; Yu, D; Zhao, X; Zhou, J; Medina, JC; Olson, SH Structure-based design of novel inhibitors of the MDM2-p53 interaction. J Med Chem 55:4936-54 (2012) [PubMed] Article
More Info.:
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP