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Target
Aurora kinase B-A
Ligand
BDBM14210
Substrate
n/a
Meas. Tech.
ChEMBL_874448 (CHEMBL2184333)
IC50
45±n/a nM
Citation
 Elkins, JM; Santaguida, S; Musacchio, A; Knapp, S Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem 55:7841-8 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B-A
Synonyms:
AUKBA_XENLA | Aurora/IPL1-related kinase 2-A | Serine/threonine-protein kinase 12-A | Serine/threonine-protein kinase aurora-B-A | XAIRK2-A | airk2-a | aurkb-a | xAurora-B
Type:
PROTEIN
Mol. Mass.:
41755.74
Organism:
Xenopus laevis
Description:
ChEMBL_874448
Residue:
361
Sequence:
MSYKENLNPSSYTSKFTTPSSATAAQRVLRKEPYVSTFTTPSDNLLAQRTQLSRITPSASSSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQSTQSK
  
Inhibitor
Name:
BDBM14210
Synonyms:
4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)-quinazoline | CHEMBL202721 | N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide | ZM447439
Type:
Small organic molecule
Emp. Form.:
C29H31N5O4
Mol. Mass.:
513.5875
SMILES:
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: