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Target
Aurora kinase B-A
Ligand
BDBM13534
Substrate
n/a
Meas. Tech.
ChEMBL_874448 (CHEMBL2184333)
IC50
19±n/a nM
Citation
 Elkins, JM; Santaguida, S; Musacchio, A; Knapp, S Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem 55:7841-8 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B-A
Synonyms:
AUKBA_XENLA | Aurora/IPL1-related kinase 2-A | Serine/threonine-protein kinase 12-A | Serine/threonine-protein kinase aurora-B-A | XAIRK2-A | airk2-a | aurkb-a | xAurora-B
Type:
PROTEIN
Mol. Mass.:
41755.74
Organism:
Xenopus laevis
Description:
ChEMBL_874448
Residue:
361
Sequence:
MSYKENLNPSSYTSKFTTPSSATAAQRVLRKEPYVSTFTTPSDNLLAQRTQLSRITPSASSSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQSTQSK
  
Inhibitor
Name:
BDBM13534
Synonyms:
CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide | VX-680 | VX680 | cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide
Type:
Small organic molecule
Emp. Form.:
C23H28N8OS
Mol. Mass.:
464.586
SMILES:
CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Structure:
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