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Target
D(3) dopamine receptor
Ligand
BDBM50115277
Substrate
n/a
Meas. Tech.
ChEMBL_880030 (CHEMBL2213379)
Ki
1.4±n/a nM
Citation
 Gogoi, S; Biswas, S; Modi, G; Antonio, T; Reith, ME; Dutta, AK Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. ACS Med Chem Lett 3:991-996 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50115277
Synonyms:
(2R,3R)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | (2R,3S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | (2S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | (2S,3R)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | (S)-(-)-5-hydroxy-2-(N,N-di-n-propylamino)tetralin | (S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | (S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol.HCl | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | CHEMBL269004
Type:
Small organic molecule
Emp. Form.:
C16H25NO
Mol. Mass.:
247.3758
SMILES:
CCCN(CCC)[C@H]1CCc2c(O)cccc2C1 |r|
Structure:
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