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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50401859
Substrate
n/a
Meas. Tech.
ChEMBL_886105 (CHEMBL2210027)
IC50
36.1±n/a nM
Citation
 Riganas, S; Papanastasiou, I; Foscolos, GB; Tsotinis, A; Serin, G; Mirjolet, JF; Dimas, K; Kourafalos, VN; Eleutheriades, A; Moutsos, VI; Khan, H; Georgakopoulou, S; Zaniou, A; Prassa, M; Theodoropoulou, M; Mantelas, A; Pondiki, S; Vamvakides, A New adamantane phenylalkylamines withs-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain. J Med Chem 55:10241-61 (2012) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50401859
Synonyms:
CHEMBL2204677
Type:
Small organic molecule
Emp. Form.:
C37H46N2
Mol. Mass.:
518.7745
SMILES:
C(CN1CCN(Cc2ccccc2)CC1)Cc1ccc(cc1)C(c1ccccc1)C12CC3CC(CC(C3)C1)C2 |TLB:22:29:32.31.36:34,THB:22:29:32:36.35.34,37:29:32:36.35.34,37:35:32:38.30.29,30:31:34:38.29.37,30:29:32.31.36:34|
Structure:
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