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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50402239
Substrate
n/a
Meas. Tech.
ChEMBL_885405 (CHEMBL2216146)
IC50
1810±n/a nM
Citation
 Van der Walt, MM; Terre'Blanche, G; Lourens, AC; Petzer, A; Petzer, JP Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B. Bioorg Med Chem Lett 22:7367-70 (2012) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50402239
Synonyms:
CHEMBL2204774
Type:
Small organic molecule
Emp. Form.:
C15H13NS
Mol. Mass.:
239.335
SMILES:
N#Cc1ccc(SCCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: