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Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM50402289
Substrate
n/a
Meas. Tech.
ChEMBL_885588 (CHEMBL2210857)
IC50
1800±n/a nM
Citation
 Bakmiwewa, SM; Fatokun, AA; Tran, A; Payne, RJ; Hunt, NH; Ball, HJ Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorg Med Chem Lett 22:7641-6 (2012) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_MOUSE | IDO-2 | Ido2 | Indol1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
45256.34
Organism:
Mus musculus
Description:
ChEMBL_105489
Residue:
405
Sequence:
MEPQSQSMTLEVPLSLGRYHISEEYGFLLPNPLEALPDHYKPWMEIALRLPHLIENRQLRAHVYRMPLLDCRFLKSYREQRLAHMALAAITMGFVWQEGEGQPQKVLPRSLAIPFVEVSRNLGLPPILVHSDLVLTNWTKRNPEGPLEISNLETIISFPGGESLRGFILVTVLVEKAAVPGLKALVQGMEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPDIFYSVIRIFLSGWKDNPAMPVGLVYEGVATEPLKYSGGSAAQSSVLHAFDEFLGIEHCKESVGFLHRMRDYMPPSHKAFLEDLHVAPSLRDYILASGPGDCLMAYNQCVEALGELRSYHINVVARYIISAATRARSRGLTNPSPHALEDRGTGGTAMLSFLKSVREKTMEALLCPGA
  
Inhibitor
Name:
BDBM50402289
Synonyms:
TENATOPRAZOLE
Type:
Small organic molecule
Emp. Form.:
C16H18N4O3S
Mol. Mass.:
346.404
SMILES:
COc1ccc2[nH]c(nc2n1)S(=O)Cc1ncc(C)c(OC)c1C
Structure:
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