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Target
Alpha-mannosidase 2
Ligand
BDBM50168990
Substrate
n/a
Meas. Tech.
ChEMBL_885340 (CHEMBL2215203)
Ki
25900±n/a nM
Citation
 Moorthy, NS; Brás, NF; Ramos, MJ; Fernandes, PA Virtual screening and QSAR study of some pyrrolidine derivatives asa-mannosidase inhibitors for binding feature analysis. Bioorg Med Chem 20:6945-59 (2012) [PubMed]  Article 
Target
Name:
Alpha-mannosidase 2
Synonyms:
Alpha-mannosidase 2A1 | Golgi alpha-mannosidase II | Lysosomal acid alpha-mannosidase | MA2A1_HUMAN | MAN2A1 | MANA2 | Mannosidase alpha class 2A member 1 | Mannosidase alpha class 2B member 1 | Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Type:
Protein
Mol. Mass.:
131156.65
Organism:
Homo sapiens (Human)
Description:
Q16706
Residue:
1144
Sequence:
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR
  
Inhibitor
Name:
BDBM50168990
Synonyms:
(2R,3R,4S)-2-[((R)-Phenyl-1-(S)-2-hydroxy-2-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol | CHEMBL361899
Type:
Small organic molecule
Emp. Form.:
C19H24N2O3
Mol. Mass.:
328.4055
SMILES:
O[C@@H]([C@@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: